The Comfort Inn and Suites Near Medical Center hotel in San Antonio, TX will get you rested and ready to go for business or leisure. Were near San Antonio River Walk, South Texas Medical Center and San Antonio International Airport. Our valued guests enjoy amenities that include free hot breakfast, free WiFi, fitness center, valet cleaning and a business center with copy and fax. Each comfortable guest room features a refrigerator, microwave, coffee maker, desk, Flat-Screen TV, hair dryer, iron and ironing board. Select rooms offer a sofa sleeper, a hot tub bathtub and wet bar. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.